Cav-1, ACC1and FASN expression is significantly increased in metastatic PCa compared to primary treated and untreated PCa (P=0.0001 and P<0.0001 for Cav-1, P=0.046 and P=0.047 for ACC1 respectively, P=0.013 and p=0.013 for FASN respectively) (Figure 6A). Here, FASN is linked to posterior cortical atrophy.