Furthermore, to investigate whether the altered interaction of O-GlcNAc or OGT with HCF-1 in cervical cancer tissues is attributable to glucose availability, we examined the interaction of HCF-1 with O-GlcNAc or OGT in cervical cancer cells exposed to low or high glucose by immunoprecipitation assay. The gene discussed is HCFC1; the disease is cervical carcinoma.