Because HCF-1 is stabilized by O-GlcNAcylation [16], and a transcription co-factor involved in oncogenic viral reactivation processes, playing a critical role in tumor formation, we tested the effects of OGT overexpression on HCF-1 in HeLa cervical cancer cells transfected with Flag or Flag-OGT. The gene discussed is HCFC1; the disease is cervical carcinoma.