OGT and cancer: Because the OGT and O-GlcNAcylation levels are elevated in various cancers, and OGT partners with transcriptional regulator such as HCF-1, and proteolytic processing of HCF-1 is required for activating the function of HCF-1 [15, 16, 18], we examined the O-GlcNAcylation and HCF-1 levels in cervical cancer tissues by western blot and immunohistochemistry analysis.