Important examples that trigger CRC are adenomatous polyposis coli (APC), Kirsten rat sarcoma viral oncogene homolog (KRAS), β-catenin, SMAD family member (SMAD) 2/4, metastasis associated in colon cancer (MACC) 1, programmed cell death (PDCD) 4, tumor suppressor protein p53, and the unbalanced Wingless-type MMTV integration site family (Wnt) signaling pathway [1,3,4,5,6,7]. The gene discussed is APC; the disease is colorectal carcinoma.