S100A4 and neoplasm: S100A4 has been shown to contribute to both demands in CRC: serving as biomarker, which allows the prognosis of patient survival and metachronous metastasis already in early stages being determined in tumor tissue or non-invasively in liquid biopsies; and serving as therapeutic target, since its down-regulation by e.g., small molecules restricts metastasis formation in mice and is currently tested in clinical trials.