It was also found that EGFR phosphorylation in wild type mice was higher than that in waved-2 mice, in which EGFR tyrosine kinase activity was reduced by 90%, and treatment with suramin, an inhibitor of multiple RTKs, including EGFR, could improve renal fibrosis by inhibiting α-SMA, TGF-β, Smad3, STAT3, ERK1/2 expression [16]. This evidence concerns the gene TGFB1 and renal fibrosis.