In both mice and humans with rapidly progressive glomerulonephritis (RPGN), Bollée et al. [62] found de novo induction of HB-EGF in intrinsic glomerular epithelial cells (podocytes) and its induction increased phosphorylation of EGFR in mice with RPGN [62]. The gene discussed is HBEGF; the disease is rapidly progressive glomerulonephritis.