One study demonstrates that administration of a selective and potent inhibitor of VEGF to rat with crescentic glomerulonephritis, one type of VEGFR, soluble Fms-like tyrosine kinase receptor 1 (sFlt-1) accelerates proteinuria with massive ascites, glomerulosclerosis and interstitial fibrosis, which is also associated with a loss of nephrin and endothelium [40]. This evidence concerns the gene VEGFA and glomerulosclerosis.