Meanwhile, since VEGF and VEGFR are involved in the regulation of podocyte function, they play key roles in the pathogenesis of glomerulonephritis, which is demonstrated in minimal change nephropathy (MCD), membranous glomerulonephritis, membranoproliferative glomerulonephritis, mesangioproliferative glomerulonephritis, focal segmental glomerulosclerosis (FSGS), and IgA nephropathy [22]. The gene discussed is KDR; the disease is focal segmental glomerulosclerosis.