In the present study, MCT1 plasma membrane expression was associated with HIF-1α and CAIX in human GBM tissues and a similar pattern was observed in CAIX in the CAM U251 microtumors and U87-MG intracranial mice brain tumors, which supports the association of MCT1 expression with hypoxic tumors regions. The gene discussed is HIF1A; the disease is glioblastoma.