FLT3 and neoplasm: In this model, oral administration of quizartinib showed a potent anti-tumor effect on sole ITD-FLT3 cell-inoculated mice, while the inhibitory effect of quizartinib was significantly lower in Wt- and ITD co-expressing cell-inoculated mice than sole ITD-FLT3 cell-inoculated mice (Figure 2A-2B).