FLT3 and leukemia: Consistent with these results, the GI50 value of quizartinib against MOLM-14, a human leukemia cell line expressing both Wt- and ITD-FLT3, was significantly increased by FL compared with MV4;11 cells harboring a homozygous ITD allele, while the impaired inhibitory effect of lestaurtinib caused by FL was limited in MOLM-14 cells (Figure 1B).