The C allele of the SNP rs1063320 showed significant increase in the SLE patients positive for anti-Sm antibody (P = 0.020, PFDR = 0.040, OR 1.29, 95%CI 1.04–1.60) and in those positive for anti-RNP antibody P = 0.013, PFDR = 0.039, OR 1.31, 95%CI 1.06–1.62) when compared with healthy controls (Table 4). Here, RNPC3 is linked to systemic lupus erythematosus.