These results implied that HLA-G 14bp ins allele has an independent contribution for early-onset SLE, while the association of rs1063320 C with anti-Sm and anti-RNP production is dependent on LD between the protective DRB1*13:02 and rs1063320 G allele. The gene discussed is HLA-DRB1; the disease is systemic lupus erythematosus.