Significant protection against overall SLE was observed for 14bp del-rs1063320 G haplotype carrying DRB1*13:02, but not for the same HLA-G haplotype carrying other DRB1 alleles, suggesting that the protective effect against overall SLE is mediated by DRB1*13:02 rather than HLA-G. Here, HLA-DRB1 is linked to systemic lupus erythematosus.