These 7 target genes along with TNFα were activated in type I SMA mice on postnatal day 8, part of them (TNFα, Serpine1, Ptgs2, Gata6 and Cntn1) were increased in type III SMA mice at the age of 6 months, and all did not obviously differ from controls in type I SMA mice on postnatal day 1 (Table 2). The gene discussed is TNF; the disease is spinal muscular atrophy, type 1.