In type I SMA mice on postnatal day 8 (severe symptomatic stage), 3 biological pathways were activated: TNFα-Bmp4-Serpine1-Gata6, TNFα-Ptgs2-Bcl2, and TNFα-IL6-Cntn1. This evidence concerns the gene CNTN1 and spinal muscular atrophy, type 1.