Several studies performed in different populations worldwide have demonstrated the association of TNF-α-308A allele related higher expression levels of TNF-α with susceptibility to, progression, metastasis, prognosis, survival and overall outcome of several types of malignant human neoplasms and have established it as a putative risk factor for developing immune related and otherwise, malignant neoplastic disease including colorectal cancer. This evidence concerns the gene TNF and cancer.