Tollip was reported to have the negatively regulatory function in mammalian (Burns et al. 2000; Rebl et al. 2008), while its expression was up-regulated in viral infected trout (Rebl et al. 2008) and grass carp (Huang et al. 2012), which relates to that the up-regulation of Tollip in fish may counteract the infection-related pro-inflammatory activation of the innate immune system and protect against pathological effects (Rebl et al. 2010). The gene discussed is TOLLIP; the disease is infection.