RASSF1 and neoplasm: Yu et al. (2010) reported that PCDH10 methylation was detected in 82% (85 of 104) of gastric tumors whereas it was found in only 37% (38 of 104) of paired non-tumor tissues (p < 0.001); while the study of Li et al. (2012a); Li et al. (2012b) showed an even a higher rate of hypermethylation at 86% of gastric cancer tissues and gastric cancer cell lines of PCDH10. Regarding RASSF1A, the reports provided by Joo et al. (2015) stated that 26% to 66.1% of RASSF1A methylation rates occurred in gastric cancer cell lines or tissues (Shi et al., 2014; Qu, Dang & Hou, 2013; Ye et al., 2007).