KCNQ1 and obesity due to melanocortin 4 receptor deficiency: In addition, clinical study showed that obesity and ischemic stroke modulate the methylation levels of KCNQ1 (potassium channel, voltage gated KQT-like subfamily Q, member 1) and WT1 (Wilms tumor 1) in white blood cells [47], and weight loss intervention program changed the methylation patterns of two stroke-related genes KCNQ1 and WT1 (Wilms tumor 1) in obese stroke patients [48].