Our findings indicated that while non-carriers showed a higher prevalence of the TD subtype, LRRK2 G2385R variant carriers were more likely to manifest the PIGD motor subtype, which was associated with an increased mortality risk, accelerated cognitive decline, greater severity of autonomic symptoms, and greater functional disability when compared with the TD phenotype [10, 23-25]. This evidence concerns the gene LRRK2 and Mental deterioration.