We found that the expression of death receptors, DR4 and DR5, as well as the decoy receptors, DcR1 and DcR2, was significantly higher in the CSC population compared with the bulk tumor cells (approximately 85–100 % of CSCs expressed death receptors compared with only 25 % of bulk cells; Fig. 3a). This evidence concerns the gene TNFRSF10B and neoplasm.