ANGPT1 and neoplasm: Our results were consistent with the prior studies that demonstrate that radiation is associated with decreases in VEGF and Ang1, and an increase in Ang2; these findings are potentially consistent with endothelial cell apoptosis as well as complex effects on angiogenesis and anti tumor immunity that need to be further explored in preclinical models that can better elucidate the functional consequences of the effects that we have observed.