Median levels of VEGF, Ang1, Ang2 and PlGF at baseline were 0.46 ng/mL, 14 ng/mL, 0.33 ng/mL, and 0.16 ng/mL in HNSCC patients, respectively, as compared to undetectable, 0.42 ng/mL (p < 0.0001 compared to cancer patients), undetectable/below range, and undetectable (~0.001 ng/mL). This evidence concerns the gene PGF and cancer.