Following treatment of human pancretatic cancer cells (BxPC-3, CAPAN-1 and AsPC-1) with TSA resulted in upregulation of acetyl H3, p21Waf1 and Bax levels, increased phosphorylation of p38 and diminished phosphorylation of ERK 1/2 and AKT (Zhang et al., 2008[41]). Here, AKT1 is linked to cancer.