In this study, we studied whether recombinant MAGE1-MAGE3-TBHSP70 protein vaccine targeting two members of MAGE family proteins at the same time can induce cellular cytotoxic-response toward tumor cells and whether such strategy could be an effective on in decelerate the tumor growth rate and prolong the survival rate in vivo in a PBL-Hu-SCID model. The gene discussed is MAGEA3; the disease is neoplasm.