Rodent cell lines that ectopically express the human SCARB2 (hSCARB2) protein, however, could be successfully infected with EV71.22, 38 Transgenic mice that express hSCARB2 also exhibited more severe signs of EV71-induced disease.21, 39 Thus, the incompatibility of EV71 with murine SCARB2 (mSCARB2) governs the restriction of EV71 infection of murine cells, and circumventing this incompatibility leads to an environment more conducive to infection. This evidence concerns the gene SCARB2 and infection.