Recently, it was reported that a 4-wk administration of β-aminopropionitrile monofumarate (BAPN), an inhibitor of lysyl oxidase (LOX), combined with a 24-h infusion of Ang II, induced aortic dissection (AD) rupture in wildtype FVB mice, while BAPN administration alone caused dissection in about 10% of these mice8. This evidence concerns the gene LOX and Alzheimer disease.