Similarly, the emergence of glucose intolerance with age in βVps13cKO mice, which is reminiscent of changes seen after the inactivation of the T2D GWAS gene Tcf7l2 in mice (43, 82), seems to reflect, at least in part, increasing insulin resistance as well as impaired insulin output from the pancreas. Here, TCF7L2 is linked to Glucose intolerance.