AKT1 and cancer: As expected, compared with the pCDH-vector transfected control cells, AKT-knockdown PC3 and DU145 cells showed reduction in cancer cell growth (P < 0.05 for all; Figure 8E and Figure 9A–9B) and angiogenesis (P < 0.01 for all; Figure 8F and Figure 9C–9D) in vitro and in vivo, similar to the phenotype observed upon Kidins220-knockdown.