In addition, Ki-67 positive cells were significantly reduced in PC3 cells transduced with pCDH-miR-4638-5p (P = 3.96 × 10− 2) and opposite result was observed in the PC3 cells transduced with pCDH-miR-4638-5p sponge (P = 3.51 × 10−2) (Figure 3D and 3E), suggesting that miR-4638-5p reduced tumor growth in the nude mouse model through inhibiting cell proliferation. Here, MKI67 is linked to neoplasm.