PIK3CA and neoplasm: Multivariate analysis was performed including these 5 parameters (p < 0.1 in univariate analysis, Table 1): only PIK3CA (p = 0.0055) high expression remained an independent significant prognostic factor for DFI, but not PDGFRB (p = 0.10) and CCND1 (p = 0.22) expression, HPV status (p = 0.21) and tumor location (p = 0.42) (Table 5).