Tumor sections from these mice showed that paclitaxel moderately inhibited proliferation (Ki67+ cells) and enhanced apoptosis (cleaved caspase3+ cells) (Figure 5B), but the combined BIBR1532 and paclitaxel treatment significantly reduced the number of proliferative cells and increased the number of apoptotic cells (Figure 5B). This evidence concerns the gene MKI67 and neoplasm.