In total, 6 miRNAs (let-7a-5p, miR-16-5p, miR-27b-3p, miR-34a-5p, miR-125b-5p and miR-148a-3p) revealed the elevated expression levels with fold-change > 2 by a dose-dependent manner in a hormone-positive (both estrogen and progesterone receptors) breast cancer line, MCF-7 (Figure 5A). The gene discussed is PGR; the disease is breast cancer.