In addition to the inflammation pathway, several cancer-related pathways were identified from the global NSAIDs-regulating miRNA-gene subnetwork, including cell cycle (CDK6, CCND1, CCKN1A, and E2F1), proliferation (MYC), apoptosis (BCL2) and angiogenesis (VEGFA) [35]. This evidence concerns the gene E2F1 and cancer.