HIG2 is highly expressed in several malignant tumors, including ovarian cancer [37], cervical cancer [36], head-and-neck squamous cell carcinomas [38], renal cell carcinoma [14, 18, 37, 39]], lymphoma [40] and colorectal cancer [13], and was shown to be induced by hypoxia [13, 18, 41]. This evidence concerns the gene HILPDA and renal cell carcinoma.