GSCs are suggested to be the driving force behind GBM growth and progression [9, 10], and hypoxia promotes GSC maintenance by inducing a cohort of important genes such as hypoxia inducible factors (HIFs, including HIF1α and HIF2α) [5, 11], mesenchymal markers [6, 7], ZNF217 [12], CDH5 [2] and others. The gene discussed is EPAS1; the disease is glioblastoma.