Multivariable analysis revealed that tumor recurrence was associated with larger tumor size (HR=1.30 (95% CI: 1.04-1.63), p=0.022), higher serum HBV DNA level (HR=1.11 (95% CI: 1.03-1.20), p=0.005), and serum AFP level ≥20 ng/mL (HR=1.66 (95% CI: 1.17-2.36), p=0.005). The gene discussed is AFP; the disease is neoplasm.