In patients with tumor size ≥2 cm, multivariable analysis showed that tumor recurrence was associated with increased PT-INR (HR=8.72 (95% CI: 2.06-36.91), p=0.003), and serum AFP level ≥20 ng/mL (HR=1.83 (95% CI: 1.17-2.86), p=0.009). The gene discussed is AFP; the disease is neoplasm.