PRKN and lung carcinoma: After the PARK2 gene was expressed in seven lung cancer cell lines (H1437, H522, H1650, A549, H460, H1299 and H196), the growth of tumor cell lines was significantly inhibited compared to controls (Figure 4D, 4E and 4F), which suggests that PARK2 overexpression plays a critical role in the inhibition of lung cancer cell proliferation [28].