While it has been shown that CD1d disruption both globally18, 19 and selectively in adipocytes ameliorates the development of obesity, other research groups have reported that CD1d disruption enhances the development of obesity and that iNKT cells in adipose tissue produce IL-4 and IL-10 that induce M2 macrophages15, 16, 17. The gene discussed is CD1D; the disease is obesity due to melanocortin 4 receptor deficiency.