Our data showed that preactivation of AD-MSCs with either TNF-α or IFN-γ significantly upregulated the expression of TRAIL and DKK-3 compared to naïve AD-MSC and TNF-α plus IFN-γ activated MSCs (P < 0.001 and P < 0.05 respectively). This evidence concerns the gene DKK3 and Alzheimer disease.