Bone marrow mononuclear and granulocytes from 2 CML patients were isolated and infected with pLenti6.3-SH2-IRES2-EGFP or pLenti6.3-SH2-U-box-IRES2-EGFP and then BCR-ABL signaling pathway and cell growth were examined. The gene discussed is BCR; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.