The 8 known pQTLs along with the kallikrein pQTL are associated with a variety of phenotypes, including age-related macular degeneration (C3b), activated partial thromboplastin times (F12), serum metabolites (KLKB1), binding of LBP to lipopolysaccharide (LBP), and plasma plasminogen levels (LP(a)). The gene discussed is KLK4; the disease is age-related macular degeneration.