IGFBP3 and osteoarthritis, hip: Some of these genes are involved in well‐described IGF regulatory or signaling pathways (such as IGFBP3 and IGFALS) (Deal et al., 2001; Gu et al., 2010; Schumacher et al., 2010) and are believed to influence traits that are also associated with concentrations or bioactivity of IGFs (e.g., FOXO3 locus associated with longevity (Willcox et al., 2008) and IGFBP3 locus associated with hip osteoarthritis (Evans et al., 2015)).