Soon after the identification of the CFH locus, another modestly sized GWAS performed on 96 cases and 130 controls yielded a genome-wide significant signal on 10q26, another primary locus for AMD that contains the candidate genes ARMS2/HTRA1 (age-related maculopathy susceptibility 2/HtrA serine peptidase 1) coding for a protein of unknown function and a serine protease, respectively [54, 57]. This evidence concerns the gene HTRA1 and age-related macular degeneration.