This study combined sequencing-based genotypes, with the exome chip genome-wide genotyping data, with SNP genotyping to uncover K155Q (OR = 2.8) in the complement component C3 gene (C3) and P167S (OR = 2.2) in C9 as contributors to AMD disease pathophysiology. The gene discussed is C9; the disease is age-related macular degeneration.