CFH and age-related macular degeneration: Remarkably, modest GWAS analysis on 96 cases and 50 controls yielded a genome-wide significant signal (P < 10−7) on 1q32 of a common single nucleotide polymorphism (SNP) on a gene encoding CFH that revealed a polymorphism in linkage disequilibrium, Y402H, that has proven to be a common, predisposing allele that confers a two- to sevenfold increased risk for developing AMD [6, 9, 55, 56].