Linkage of an AMD locus to 1q32 [4, 5], and the genome-wide association at the complement factor H (CFH) locus [6] led to the identification of the first common genome-wide significant risk variant, Y402H, that has upon sequencing in ethnic stratified cohorts revealed differential frequencies ranging from 5 % in East Asian populations to 35 % in European populations [7, 8]. The gene discussed is CFH; the disease is age-related macular degeneration.