The mechanism by which HuR regulates tumor cell migration and invasion is documented to involve several oncoproteins such as actin, matrix metalloprotease (MMP)-9, urokinase-type plasminogen activator (uPA) and its receptor (uPAR), and the CXCR-4 chemokine receptor all of which are known to play an important role in cancer cell migration and invasion resulting in metastasis [16, 53, 54]. The gene discussed is PLAUR; the disease is neoplasm.