THEM4 and neoplasm: Since Maira et al. published the original study describing 27-kDA CTMP as an Akt-interacting protein in 200111, accumulating evidence suggests that CTMP binds to the Akt carboxy terminus and negatively regulates its activity in lung cancer33, glioblastoma34, 35, pancreatic adenocarcinoma36, and cervical cancer cell lines37, suggesting CTMP is a tumor suppressor.