In conclusion, our data suggest that CTMP functions as a positive regulator of Akt and facilitates HNSCC invasion such as LN metastasis by regulating EMT in a Snail-dependent manner indicating the oncogenic activity of CTMP in HNSCC, and its expression is an independent predictor of clinical prognosis and response to platinum-based chemotherapy in HNSCC. The gene discussed is THEM4; the disease is head and neck squamous cell carcinoma.