In conclusion, our data suggest that CTMP functions as a positive regulator of Akt and facilitates HNSCC invasion such as LN metastasis by regulating EMT in a Snail-dependent manner indicating the oncogenic activity of CTMP in HNSCC, and its expression is an independent predictor of clinical prognosis and response to platinum-based chemotherapy in HNSCC. Here, AKT1 is linked to head and neck squamous cell carcinoma.