Removing Mecp2 from SIM-1 expressing hypothalamic neurons, for example, results in hyperphagia, obesity and aggression (Fyffe et al., 2008), whereas deficiency of MeCP2 in somatostatin-positive neurons causes seizures and stereotypies (Ito-Ishida et al., 2015). This evidence concerns the gene MECP2 and obesity due to melanocortin 4 receptor deficiency.