These GABAergic conditional knockout mice reproduce most of the features observed in the Mecp2-null mice: premature lethality, stereotyped forepaw motions and other repetitive behaviors, abnormal social interaction, learning and memory deficits, hypoactivity, ataxia, and hindlimb clasping (Chao et al., 2010). Here, MECP2 is linked to cerebellar ataxia.