MECP2 and Tremor: This indicates that the development of tremor is particularly dependent on proper excitatory network activity; indeed, loss of Mecp2 from GABAergic neurons does not result in tremor (Chao et al., 2010), while glutamatergic conditional knockout mice do develop a tremor which is not observed in glutamatergic conditional rescue mice (see companion paper Meng et al., 2016).