For patients with GH and Gn deficiencies, mortality risk was compared between treated and untreated patients, as a proportion of deficient patients were not on replacement; in the case of HC and LT4 replacement, which is mandatory in ACTH and TSH deficiencies, respectively, the effect of daily replacement doses on relative mortality risk was also examined. The gene discussed is POMC; the disease is mucopolysaccharidosis type 3D.