POMC and acromegaly: Zueger et al. 18 also found increased mortality with higher hydrocortisone dosages in ACTH‐deficient NFPA patients in a Swiss study; this finding was consistent for both total and weight‐adjusted hydrocortisone doses, and the same associations have been observed in acromegaly.11 Interestingly, we found that daily replacement doses of LT4 below 100 mcg in TSH‐deficient patients were associated with a higher mortality risk.