The present study was able to calculate nominal causal estimates for IBD, Crohn disease, psoriatic arthritis, CAD, eGFRcr, serum albumin level, and serum protein level using CRP GRSGWAS, but the estimates were altered by removal of SNPs from GRSGWAS based on heterogeneity tests, resulting in nominal or nonsignificant associations. This evidence concerns the gene CRP and inflammatory bowel disease.