IV analyses provided nominal evidence for potential causal relationships of lnCRP with risk of Crohn disease (OR 0.78 [95% CI 0.65–0.94]; p < 0.009), psoriatic arthritis (1.45 [1.04–2.04]; p < 0.03), and schizophrenia (0.90 [0.82–0.99]; p < 0.03), and with an increase in systolic blood pressure (SBP) (mean increase 1.23 mm Hg per 10-s% increase in CRP level [95% CI 0.45–2.01]; p < 0.002) and diastolic blood pressure (DBP) (0.70 [0.20–1.19]; p < 0.006). Here, CRP is linked to schizophrenia.