In a follow-up analysis using the individual-level PGC data, we found that a GRS incorporating the same 18 CRP SNPs used to construct the GRSGWAS was again significantly associated with a lower risk of schizophrenia (OR 0.96 [95% CI 0.94–0.98]; p < 1.72 × 10−6). Here, CRP is linked to schizophrenia.