In this large-scale cross-consortium MR study of 32 complex outcomes, we found evidence for a potential protective causal relationship between elevated CRP level and schizophrenia in both genetic IVs (i.e., GRSCRP and GRSGWAS) and confirmed this protective relationship in follow-up analyses using individual-level genotype data from the schizophrenia GWAS. Here, CRP is linked to schizophrenia.