The stepwise adjustment in the GRSGWAS resulted in the removal of two SNPs from the GRSGWAS for celiac disease (in PABPC4 and PTPN2), one SNP from the GRSGWAS for ulcerative colitis (in GCKR), five SNPS from the GRSGWAS for rheumatoid arthritis (in HNF4A, IL6R, SALL1, NLRP3, and PTPN2), one SNP from the GRSGWAS for type 1 diabetes (in PTPN2), and one SNP from the GRSGWAS for type 2 diabetes (in APOC1). The gene discussed is NLRP3; the disease is rheumatoid arthritis.