The specific cell clones were selected with a view to cover a broad range of cellular differentiation states and work with models that are popular for PrP-related studies, either because they are known to be susceptible to infection (N2a, C2C12, 1C11, mouse) and/or have retained the ability to (trans)differentiate (C2C12: myoblast to myotube; NMuMG: epithelial to mesenchymal state; 1C11: neuroectodermal to neuronal cells with sprouting neurites). Here, PRNP is linked to infection.