In line with results obtained from electrophoresis, the levels of lipocalin-1, lactotransferrin, extracellular glycoprotein lacritin, lysozyme-C, and prolactin inducible protein were significantly decreased, while the level of dermcidin was significantly elevated in AD tears, as compared to those of the controls (Fig 3,Table 2). This evidence concerns the gene PIP and Alzheimer disease.