These authors carried out an independent GWAS with 1294 ND cases (defined by FTND score) and 2071 non-ND controls who had smoked at least 1 cigarette, revealing that the genetic locus most strongly associated with ND was rs1451240 in CHRNB3 (odds ratio (OR) 0.65; P=2.4 × 10−8). The gene discussed is CHRNB3; the disease is Norrie disease.