In conclusion, here we have demonstrated the NF-κB mediated upregulation of TBX15 in cancer cells, identifying two NF-κB functional motifs in the 5’-flanking region of TBX15. This novel finding together with our previous discovery of an antiapoptotic function of TBX15, support the implication of TBX15 in carcinogenesis. Here, TBX15 is linked to cancer.