Stabilisation of the HIF-1α subunit occurs, e.g., in the case of a deletion or inactivating mutation in the gene for the VHL protein, which determines the development of tumours, such as human glioblastoma or sporadic renal cell carcinoma (Latif et al. 1993; Ohh 2006; Pugh and Ratcliffe 2003). This evidence concerns the gene VHL and neoplasm.