In one study, Mtiraoui et al reported that the prevalence of AAin A1298C in RPL group was significantly higher than the control, but in three separate studies, Hohlagschwandtner et al, Khaleghparast et al, and Poursadegh et al showed no relationship between C677T or A1298C polymorphisms in MTHFR with recurrent spontaneous abortion (35-38). Here, MTHFR is linked to abortion.