Among these six CpG-regulating genes, DPYSL2 is known to be associated with schizophrenia and bipolar disorder (Fallin et al., 2005); while TCN2 is associated with various disorders including Alzeimer’s disease, vascular disease, and certain cancers (e.g., brain and colorectal) (Hazra et al., 2010). This evidence concerns the gene TCN2 and bipolar disorder.