Among these six CpG-regulating genes, DPYSL2 is known to be associated with schizophrenia and bipolar disorder (Fallin et al., 2005); while TCN2 is associated with various disorders including Alzeimer’s disease, vascular disease, and certain cancers (e.g., brain and colorectal) (Hazra et al., 2010). Here, TCN2 is linked to cancer.