Studies have shown that in individuals homozygous for Ala379Val this enzyme production had reduced and it may lead to less risk for CHD.15 As migraine is a vascular disorder and Lp-PLA2 has some vascular effects, the aim of this study was to investigate the association of migraine without aura and Ala379Val polymorphism in Iranian population. The gene discussed is PLA2G7; the disease is migraine disorder.