SLC8A1 and Hypertension: Indeed, perinatal DDT exposure induced the mRNA expression of several Na+/H+ exchangers, two Na+/K+/Cl– cotransporters, a subunit of the Na+/K+ ATPase, and a Na+/Ca2+ exchanger in hypertensive kidneys (Figure 3B), consistent with elevated expression of renal ion transporters in hypertension caused by an over-activated RAS (Rozansky 2006).