While ET2 may herald a full-blown EMT during tumour progression, these processes seem to be independent in lung adenocarcinoma, where GATA6low BAS-L tumours lack EMT features.40 More investigations are required to assess the putative sequence from ET2 to EMT in other tumour types and a more general role of the GATA and FOXA protein families. This evidence concerns the gene EDN2 and lung adenocarcinoma.