EMT plays an important role in tumour progression and spreading20, 21 and is associated with the outcome in patients with PDAC.22 Consistently, GATA6-silenced PaTu8988S and SK-PC-1 cells displayed increased capacity to invade in vitro (figure 2A and see online supplementary figure S2E), while invasiveness was reduced in L3.6pl cells overexpressing GATA6 (figure 2B). Here, GATA6 is linked to neoplasm.