In conclusion, we provide here a thorough mechanistic analysis of GATA6 function in PDAC cells, where it inhibits EMT, basality and dissemination, supporting its role as a PDAC tumour suppressor, further strengthened by the genomic losses that we and others observed, and by the hypermethylation of GATA6 promoter described recently.52 Finally, we propose GATA6 as a valuable marker to guide patient treatment. Here, GATA6 is linked to neoplasm.