GATA6 also represses a basal-like transcriptional programme similar to the one described in breast and bladder36, 38, 42, 43 and, more recently, in PDAC.23 Loss of canonical differentiation was previously associated with low GATA6, both in PDAC12 and in lung cancer.40 Furthermore, a GATA6-overexpression signature was enriched in the classical PDAC subtype described recently.23 However, a mechanistic explanation was completely missing. Here, GATA6 is linked to lung cancer.