To explore the roles of miR-106a/b in breast cancer stem like cell properties by targeting STAT3 and HIF-1α, SUM102 cells were tranfected with miR-106a/b and STAT3 siRNA or HIF-1α in the present of CM from the co-cultured with Hs578Bst fibroblasts and breast cancer cells. The gene discussed is STAT3; the disease is breast cancer.