BSG and breast carcinoma: Breast cancer cells with EMMPRIN knocking down were treated with the conditioned medium from the fibroblasts with cancer medium treatment or co-cultured conditioned medium from breast cancer cells and fibroblasts interaction, the results of mammosphere formation assay showed that downregulation of EMMPRIN decreased the sphere formation rates in breast cancer cells by conditioned medium from cancer cell conditioned medium pre-treated Hs578Bst fibroblasts or the co-cultured conditioned medium (Fig. 3A,B).